KSHVORF45 抗体
This anti- antibody is a 单克隆 antibody detecting in ELISA 和 WB. Suitable for Human Herpesvirus 8 (HHV-8). This Primary Antibody has been cited in 3+ publications.
(3 references)Quick Overview for KSHVORF45 抗体 (ABIN966465)
抗原
KSHVORF45
适用
Human Herpesvirus 8 (HHV-8)
宿主
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克隆类型
单克隆
标记
非结合性
应用范围
ELISA, Western Blotting (WB)
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特异性
- Ni-NTA purified recombinant human KSHV ORF45 expressed in E. Coli strain BL21 (DE3).
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纯化方法
- Crude ascites.
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亚型
- IgG1
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anti-KSHVORF45 antibody
适用: Human Herpesvirus 8 (HHV-8) ELISA, IHC 宿主: 小鼠 Monoclonal 2D4A5 unconjugated
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应用备注
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Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test. -
限制
- 仅限研究用
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储存条件
- -20 °C
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: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).
: "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5573-8, (2002) (PubMed).
: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." in: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, (1995) (PubMed).
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: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).
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- KSHVORF45
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物质类
- Viral Protein
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背景
- Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediateearly gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
抗原
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